General Information

  • ID:  hor000536
  • Uniprot ID:  A0A921Z0J2
  • Protein name:  MIP V
  • Gene name:  NA
  • Organism:  Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Manduca (genus), Sphingini (tribe), Sphinginae (subfamily), Sphingidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GWQDMSSAW
  • Length:  9(56-64)
  • Propeptide:  MRCCVAVLWAFFATWAVAAAEEPHHDAAPQTDNELDLTDEDKRAWTSLRGGWAKRGWQDMSSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRGWQDLNSAWGKRSDDEAMDKRAWQDLNSAWGKRGWQDMSSAWGKRAWQDLNSAWGKRGWNDMSSAWGKRAWQDLNSAWGKRGWQDMSSAWGKRAPEKWAAFHGSWGKRAAEPDYEELDAAIEQLVPIHQMDEDRMDAPEKKAWSALHGAWGK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000536_AF2.pdbhor000536_ESM.pdb

Physical Information

Mass: 121002 Formula: C47H62N12O15S
Absent amino acids: CEFHIKLNPRTVY Common amino acids: SW
pI: 3.75 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -78.89 Boman Index: -1130
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 11.11
Instability Index: 11422.22 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1375

Literature

  • PubMed ID:  14599724
  • Title:  A Comparison of the Neuropeptides From the Retrocerebral Complex of Adult Male and Female Manduca Sexta Using MALDI-TOF Mass Spectrometry